The goal of Dr. Schlossmacher’s work as a physician-scientist is to contribute to the improved care of patients with neurodegenerative diseases. Dr. Schlossmacher has focused his research activities on Parkinson disease, as an independent investigator at the Center for Neurologic Diseases at BWH.  In his research activities, Dr. Schlossmacher is pursuing 3 related goals:

One, to explore the development of a sensitive and specific biomarker for Parkinson disease that is based on the quantification of alpha-synuclein protein in the blood and cerebrospinal fluid.

Two, to contribute to the understanding of the pathogenesis of Parkinson disease by focusing on the role of two proteins that are each causally linked to the disease, alpha-synuclein and Parkin. 

Three, to contribute to the development of a neuroprotective treatment option in Parkinson disease.  To this end, Dr. Schlossmacher has collaborated since 2002 with Dr. Rajiv Ratan (now at Cornell University’s Burke Institute in White Plains, NY) and Dr. Ross Stein at the LDDN, pursuing the up-regulation of the neuroprotective Parkin protein in dopamine-producing cells.

Michael G. Schlossmacher, M.D.
Assistant Professor of Neurology
Harvard Medical School
Associate Neurologist, Parkinson and
Movement Disorders Center
Brigham & Women’s Hospital